Article
A human laterality disorder associated with a homozygous WDR16 deletion.
European journal of human genetics : EJHG - 1 Sept 2015
Ta-Shma Asaf, Perles Zeev, Yaacov Barak, Werner Marion, Frumkin Ayala, Rein Azaria J J T, Elpeleg Orly
Abstract excerpt
The laterality in the embryo is determined by left-right asymmetric gene expression driven by the flow of extraembryonic fluid, which is maintained by the rotary movement of monocilia on the nodal cells. Defects manifest by abnormal formation and arrangement of visceral organs. The genetic etiology of defects not associated with primary ciliary dyskinesia is largely unknown. In this study, we investigated the...
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