Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Mar 2018

Gao Wei-Wei, Tang Hei-Man Vincent, Cheng Yun, Chan Ching-Ping, Chan Chi-Ping, Jin Dong-Yan

Abstract excerpt

CRTCs are a group of three transcriptional coactivators required for CREB-dependent transcription. CREB and CRTCs are critically involved in the regulation of various biological processes such as cell proliferation, metabolism, learning and memory. However, whether CRTC1 efficiently induces gluconeogenic gene expression and how CRTC1 is regulated by upstream kinase SIK1 remain to be understood. In this work, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Knockdown Techniques
Share to Gluconeogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Proteasome Endopeptidase Complex

Share to Proteolysis

Share to Serine

Share to Ubiquitin

Share to Ubiquitination

Source

Identifiers

PMID: 29408765
DOI: 10.1016/j.bbagrm.2018.01.021

Genes

CRTC1
SIK1
CRTC2
SIK2
SIK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1.PMID 29408765Read ↗

Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC).Semantic proximity Read ↗

Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus ratsSemantic proximity Read ↗

Crtc1 Deficiency Causes Obesity Potentially via Regulating PPARγ Pathway in White AdiposeSemantic proximity Read ↗

Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2.Semantic proximity Read ↗

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)Semantic proximity Read ↗

The Multifaceted Role of S6K1 in Cellular Regulation and Disease: Structural Insights, Isoform-Specific Functions, and Therapeutic PotentialSemantic proximity Read ↗

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browningSemantic proximity Read ↗

Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.Semantic proximity Read ↗

Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2.Semantic proximity Read ↗

DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.Semantic proximity Read ↗

Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle.Semantic proximity Read ↗

RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.