Back to search

Article

Immortalization-Upregulated Protein Promotes Pancreatic Cancer Progression By Regulating NPM1/FHL1-Mediated Cell-Cycle-Checkpoint Protein Activity

2021-11-22

Abstract excerpt

<title>Abstract</title> <p>Immortalization-upregulated protein (IMUP) plays a vital role in cell proliferation and tumor progression. However, its role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Here, we select <italic>IMUP</italic> as an alternative gene based on GeneChip analysis of clinical PDAC tissues and transcriptome data from The Cancer Genome Atlas. <italic>IMUP</italic> expression is up...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
874a9fb5-3c8e-56e2-b845-bc8b74ca78fc
DOI
10.21203/rs.3.rs-1077168/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Immortalization-Upregulated Protein Promotes Pancreatic Cancer Progression By Regulating NPM1/FHL1-Mediated Cell-Cycle-Checkpoint Protein ActivityDOI 10.21203/rs.3.rs-1077168/v1
Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activitySemantic proximity
The oncofetal protein IMP1 regulates the transcriptomic landscape to drive early events in pancreatic cancer progression and growthSemantic proximity
Expression of Genomic Instability-Related Molecules: Cyclin F, RRM2 and SPDL1 and Their Prognostic Significance in Pancreatic AdenocarcinomaSemantic proximity
p27Kip1 and human cancers: A reappraisal of a still enigmatic protein.Semantic proximity
PD2/PAF1 at the Crossroads of the Cancer NetworkSemantic proximity
FAT10 promotes chemotherapeutic resistance in pancreatic cancer by inducing epithelial-mesenchymal transition via stabilization of FOXM1 expressionSemantic proximity
WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinomaSemantic proximity
Loss of ARID1A Expression Correlates With Tumor Differentiation and Tumor Progression Stage in Pancreatic Ductal Adenocarcinoma.Semantic proximity
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancerSemantic proximity
PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferationSemantic proximity
ZBED2 is an antagonist of Interferon Regulatory Factor 1 and modulates cell identity in pancreatic cancerSemantic proximity
Identification of a novel target of SETD1A histone methyltransferase and the clinical significance in pancreatic cancerSemantic proximity
Select a neighboring publication to make it the new centre.