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Article

PD2/PAF1 at the Crossroads of the Cancer Network

8 Jan 2018

Abstract excerpt

Abstract Pancreatic differentiation 2 (PD2)/RNA polymerase II–associated factor 1 (PAF1) is the core subunit of the human PAF1 complex (PAF1C) that regulates the promoter-proximal pausing of RNA polymerase II as well as transcription elongation and mRNA processing and coordinates events in mRNA stability and quality control. As an integral part of its transcription-regulatory function, PD2/PAF1 plays a role in...

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PMID: 29311159
DOI: 10.1158/0008-5472.can-17-2175

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