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Article

Two Piwis with Ago-like functions silence somatic genes at the chromatin level

2020-08-25

Abstract excerpt

Most sRNA biogenesis mechanisms involve either RNAseIII cleavage or ping-pong amplification by different Piwi proteins harboring slicer activity. Here, we follow the question why the mechanism of transgene-induced silencing in the ciliate Paramecium needs both Dicer activity and two Ptiwi proteins. This pathway involves primary siRNAs produced from non-translatable transgenes and secondary siRNAs from endogenous...

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Identifiers and source

Literature Corpus work
86d31fbd-2604-5f50-bffe-7fd2d8d39154
DOI
10.1101/2020.08.24.263970
Open publication

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Two Piwis with Ago-like functions silence somatic genes at the chromatin levelDOI 10.1101/2020.08.24.263970
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