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A PIWI protein-dependent DNA N6-adenine methylation pathway in <i>Oxytricha</i> protects genomic sequences from deletion

2026-01-07

Abstract excerpt

The ciliate Oxytricha undergoes massive genome rearrangements during development to produce a functional nucleus from an encrypted zygotic genome. PIWI-interacting small RNAs protect DNA regions against deletion, but how that protective mark is established has been a mystery. Recently our lab discovered MTA1, a methyltransferase that catalyzes DNA N6-adenine (6mA) methylation. Both MTA1 and the Oxytricha Piwi pr...

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Literature Corpus work
d6d10dd5-926c-5966-be66-826b06276b4b
DOI
10.64898/2026.01.06.698049
Open publication

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