Cell-to-cell variability in inducible Caspase9-mediated cell death

Abstract excerpt

<h4>ABSTRACT</h4> iCasp9 suicide gene has been widely used as a promising killing strategy in various cell therapies. However, different cells show significant heterogeneity in response to apoptosis inducer, posing challenges in clinical applications of killing strategy. The cause of the heterogeneity remains elusive so far. Here, by simultaneously monitoring the dynamics of iCasp9 dimerization, Caspase3 activati...

Topics

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• Autophagy in Disease and Therapy
• BH3 Interacting Domain Death Agonist Protein
• CAR-T cell therapy research
• Caspase 3
• Cell death mechanisms and regulation
• Computational Drug Discovery Methods
• FOXO transcription factor regulation
• PARP inhibition in cancer therapy

Identifiers and source

Literature Corpus work

86bef18c-213b-57a0-b181-ed8c128c907c

DOI

10.1101/2021.06.08.447627