Article

Proteomic signature and mesenchymal stromal/stem cell-derived extracellular vesicle treatment of iPSC motor neurons from different ALS patient groups

2022-07-05

Abstract excerpt

<h4>Summary</h4> Motor neurons (MNs) derived from human induced pluripotent stem cells (iPSCs) offer a powerful model to study motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). While widely used, our knowledge of the proteomic changes in these models is rather rudimentary. In this study, we conducted a comparative proteomic analysis of iPSC-derived MNs carrying ALS-associated mutations in C9ORF...

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Literature Corpus work: 86b8e124-dbe6-5325-90dc-356148a45b32
DOI: 10.1101/2022.07.05.498816

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