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Article

Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors.

Oncotarget - 2 Aug 2016

Li Chien-Feng, Chuang I-Chieh, Liu Ting-Ting, Chen Ko-Chin, Chen Yen-Yang, Fang Fu-Min, Li Shau-Hsuan, Chen Tzu-Ju, Yu Shih-Chen, Lan Jui, Huang Hsuan-Ying

Abstract excerpt

The role of deregulated cellular metabolism, particularly lipid metabolism, in gastrointestinal stromal tumors (GISTs) remains unclear. Through data mining of published transcriptomes, we examined lipid metabolism-regulating drivers differentially upregulated in high-risk cases and identified monoglyceride lipase (MGLL) as the top-ranking candidate involved in GIST progression. MGLL expression status was examined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27366945
DOI: 10.18632/oncotarget.10304
PMCID: PMC5226563

Genes

MGLL
KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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