Mutant GT198 in angiogenesis as a common origin of human prostate and bladder cancers

Abstract excerpt

<h4>ABSTRACT</h4> Prostate and bladder cancers are common cancers in men. It has been speculated that the high concomitant incidence of the two cancers is due to a potential shared cause underlying both cancers. In this report, we have identified a common cause of human prostate and bladder cancers as the mutant oncoprotein GT198 ( PSMC3IP ). GT198 is a DNA repair factor and a steroid hormone receptor coactivato...

Topics

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• Ataxia Telangiectasia Mutated Proteins
• BRCA2 Protein
• Cell Cycle Proteins
• DNA Repair
• Exome Sequencing
• Neoplasm Metastasis
• Neovascularization, Pathologic
• Prostatic Neoplasms

Identifiers and source

Literature Corpus work

865e0be8-2858-5579-a19a-365636c04b47

DOI

10.1101/726679