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Targeting hypoxia-induced circSTT3A decreases breast cancer stem cell formation via degradation of PGK1 protein and serine synthesis

2023-05-01

Abstract excerpt

<h4>Background</h4> Hypoxia is a key feature of tumor microenvironment that can cause fundamental changes in cancer cells, and may also lead to the development of breast cancer stem cells (BCSCs) with self-renewal ability. However, the mechanism of hypoxia in inducing BCSCs is not fully understood. <h4>Methods</h4> Performing RNA sequence and bioinformatics analysis, a hypoxia specific circular RNA (circRNA), na...

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Literature Corpus work
ceca393a-3b41-56c2-87bb-12cd720c4621
DOI
10.1101/2023.04.28.538664
Open publication

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Targeting hypoxia-induced circSTT3A decreases breast cancer stem cell formation via degradation of PGK1 protein and serine synthesisDOI 10.1101/2023.04.28.538664
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