Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

doi:10.1038/ng.2921

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Article

Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

Nature genetics - 1 Apr 2014

Behjati Sam, Tarpey Patrick S, Sheldon Helen, Martincorena Inigo, Van Loo Peter, Gundem Gunes, Wedge David C, Ramakrishna Manasa, Cooke Susanna L, Pillay Nischalan, Vollan Hans Kristian M, Papaemmanuil Elli, Koss Hans, Bunney Tom D, Hardy Claire, Joseph Olivia R, Martin Sancha, Mudie Laura, Butler Adam, Teague Jon W, Patil Meena, Steers Graham, Cao Yu, Gumbs Curtis, Ingram Davis, Lazar Alexander J, Little Latasha, Mahadeshwar Harshad, Protopopov Alexei, Al Sannaa Ghadah A, Seth Sahil, Song Xingzhi, Tang Jiabin, Zhang Jianhua, Ravi Vinod, Torres Keila E, Khatri Bhavisha, Halai Dina, Roxanis Ioannis, Baumhoer Daniel, Tirabosco Roberto, Amary M Fernanda, Boshoff Chris, McDermott Ultan, Katan Matilda, Stratton Michael R, Futreal P Andrew, Flanagan Adrienne M, Harris Adrian, Campbell Peter J

Abstract excerpt

Angiosarcoma is an aggressive malignancy that arises spontaneously or secondarily to ionizing radiation or chronic lymphoedema. Previous work has identified aberrant angiogenesis, including occasional somatic mutations in angiogenesis signaling genes, as a key driver of angiosarcoma. Here we employed whole-genome, whole-exome and targeted sequencing to study the somatic changes underpinning primary and secondary...

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Identifiers

PMID: 24633157
DOI: 10.1038/ng.2921
PMCID: PMC4032873

Genes

PLCG1
PTPRB

Variants

Provenance

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