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Article

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease.

British journal of cancer - 1 Jul 2018

Mijuskovic Martina, Saunders Edward J, Leongamornlert Daniel A, Wakerell Sarah, Whitmore Ian, Dadaev Tokhir, Cieza-Borrella Clara, Govindasami Koveela, Brook Mark N, Haiman Christopher A, Conti David V, Eeles Rosalind A, Kote-Jarai Zsofia

Abstract excerpt

BACKGROUND: Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes. METHODS: We sequenced germline whole exomes from 139 aggressive (metastatic, age of diagnosis < 60) and 141 non-aggressive (low clinical grade, age of diagnosis ≥60) PrCa...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29915322
DOI: 10.1038/s41416-018-0141-7
PMCID: PMC6035259

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BRCA2
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