Article

Synthetic Viscoelastic Activating Cells for T Cell Engineering and Cancer Therapy

2023-09-15

Abstract excerpt

<title>Abstract</title> <p>Immunotherapy shows great promise for cancer treatment, but its effectiveness and durability remain limited. Thus, there is unmet needs for more robust technology for immune cell engineering. Here we develop a scalable microfluidic platform to fabricate synthetic viscoelastic activating cells (SynVACs) with programmable mechanical and chemical properties. We demonstrate that the viscoel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 863986ab-f962-5cc8-8e68-751e8899bef9
DOI: 10.21203/rs.3.rs-3338537/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synthetic Viscoelastic Activating Cells for T Cell Engineering and Cancer TherapyDOI 10.21203/rs.3.rs-3338537/v1Read

Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells <i>in vitro</i>Semantic proximity Read

A Microgel-Based Platform for Tunable Expansion and Function of γδ T-cellsSemantic proximity Read

Tumor Priming by Ultrasound Mechanogenetics for with SynNotch CAR T TherapySemantic proximity Read

Ultrasound-Activated Nanobubbles Induce Durable Systemic Antitumor ImmunitySemantic proximity Read

Synthetic cell-based tissues for bottom-up assembly of artificial lymphatic organsSemantic proximity Read

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptorsSemantic proximity Read

Cell-derived Nanoparticles Provide a Robust Platform to Manufacture Therapeutic T cells.Semantic proximity Read

Delivery of CAR-T Cells in a Transient Injectable Stimulatory Hydrogel Niche Improves Treatment of Solid TumorsSemantic proximity Read

Enhancing Patient Lymphocyte Response to Peritoneal Malignancies Using a Personalized Immunocompetent Microfluidic Co-Culture PlatformSemantic proximity Read

Titering of Chimeric Antigen Receptors on CAR T Cells enabled by a Microfluidic-based Dosage-Controlled Intracellular mRNA Delivery PlatformSemantic proximity Read

A Digital Microfluidic Platform for the Microscale Production of Functional Immune Cell TherapiesSemantic proximity Read

Electro-mechanical transfection for non-viral primary immune cell engineeringSemantic proximity Read