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Altered contractility in mutation-specific hypertrophic cardiomyopathy: a mechano-energetic in silico study with pharmacological insights

2022-07-01

Abstract excerpt

<h4>Introduction: </h4> Mavacamten (MAVA), Blebbistatin (BLEB), and Omecamtiv mecarbil (OM) are promising drugs directly targeting sarcomere dynamics, with demonstrated efficacy against hypertrophic cardiomyopathy (HCM) in clinical trials. However, the molecular mechanism affecting cardiac contractility regulation, and the diseased cell mechano-energetics are not fully understood yet. <h4>Methods: </h4>: We prese...

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Literature Corpus work
d7e87acc-1f87-5568-b4db-91393b4170a7
DOI
10.22541/au.165051194.48849429/v2
Open publication

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