Article

Molecular identification of hyaluronate lyase, not hyaluronidase, as an intrinsic hyaluronan-degrading enzyme in Clostridium perfringens

2024-05-02

Abstract excerpt

<title>Abstract</title> <p><italic>Clostridium perfringens</italic>, an opportunistic pathogen in the human intestine, causes gas gangrene by producing various toxins. A clostridial enzyme degrading the host extracellular matrix hyaluronan (HA) has been considered a critical virulence factor as mu-toxin hyaluronidases including endo-β-<italic>N</italic>-acetylglucosaminidases (Nags). Here we show that, distinct f...

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Literature Corpus work: 8628b0a8-7fc1-5915-90be-6362fc912456
DOI: 10.21203/rs.3.rs-4310962/v1

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