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Article

Construction and virulence testing of a collagenase mutant of Clostridium perfringens.

Microbial pathogenesis - 1 Feb 2000

Awad M M, Ellemor D M, Bryant A E, Matsushita O, Boyd R L, Stevens D L, Emmins J J, Rood J I

Abstract excerpt

Clostridium perfringens produces several extracellular toxins and enzymes, including an extracellular collagenase or kappa toxin that is encoded by the colA gene. To determine if the ability to produce collagenase was a significant virulence factor in cases of gas gangrene or clostridial myonecrosis that are caused by C. perfringens, a chromosomal colA mutant was constructed by homologous recombination and...

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Identifiers

PMID: 10644496
DOI: 10.1006/mpat.1999.0328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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