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Role of Hyaluronidase in Subcutaneous Spread and Growth of Group A Streptococcus

20 Dec 2005

Abstract excerpt

Group A streptococcus (GAS) depends on a hyaluronic acid (HA) capsule to evade phagocytosis and to interact with epithelial cells. Paradoxically, GAS also produces hyaluronidase (Hyl), an enzyme that cleaves HA. A common assumption is that Hyl digests structurally identical HA in human tissue to promote bacterial spread. We inactivated the gene encoding extracellular hyaluronidase, hylA, in a clinical Hyl(+)...

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PMID: 16368955
DOI: 10.1128/iai.74.1.40-48.2006

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