Article

Do we need to adjust for interim analyses in a Bayesian adaptive trial design?

2020-04-16

Abstract excerpt

<title>Abstract</title><p><bold>Background:</bold>Bayesian adaptive methods are increasingly being used to design clinical trials and offer several advantages over traditional approaches. Decisions at analysis points are usually based on the posterior distribution of the treatment effect. However, there is some confusion as to whether control of type I error is required for Bayesian designs as this is a frequentis...

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Literature Corpus work: 714e6bd6-5086-5010-a26d-007647cb6b55
DOI: 10.21203/rs.2.17854/v2

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