Article
An efficient basket trial design.
Statistics in medicine - 10 May 2017
Cunanan Kristen M, Iasonos Alexia, Shen Ronglai, Begg Colin B, Gönen Mithat
Abstract excerpt
The landscape for early phase cancer clinical trials is changing dramatically because of the advent of targeted therapy. Increasingly, new drugs are designed to work against a target such as the presence of a specific tumor mutation. Because typically only a small proportion of cancer patients will possess the mutational target, but the mutation is present in many different cancers, a new class of basket trials...
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