Back to search

Article

Low STING expression in a transplantable Kras <sup>G12D</sup> /P53 <sup>ko</sup> lung cancer model contributes to SiglecF <sup>+</sup> neutrophil and CD103 <sup>+</sup> Treg accumulation in tumors

2021-01-04

Abstract excerpt

Lung cancer is the leading cause of mortality by cancer worldwide. Non-small cell lung cancer is the most common type of lung cancer and mutations in the KRAS gene are frequently found in this pathology. While immune checkpoint inhibitors are providing new hope for lung cancer care, only a subset of patients show durable benefit from these new therapies designed to drive an efficient anti-tumor immune response. H...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
073ad1d9-0885-5e6f-845e-e1bf8602fb8c
DOI
10.1101/2021.01.04.425311
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Low STING expression in a transplantable Kras <sup>G12D</sup> /P53 <sup>ko</sup> lung cancer model contributes to SiglecF <sup>+</sup> neutrophil and CD103 <sup>+</sup> Treg accumulation in tumorsDOI 10.1101/2021.01.04.425311
Type I interferon signaling pathway enhances immune-checkpoint inhibition in KRAS mutant lung tumors.Semantic proximity
Therapeutic KRAS <sup>G12C</sup> inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancersSemantic proximity
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers.Semantic proximity
Prognostic Value and Oncogenic Role of STING-Related Genes GAB3 and IL16 in Lung Adenocarcinoma: Implications for Immune Evasion and TreatmentSemantic proximity
Lung adenocarcinoma–derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokinesSemantic proximity
STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype.Semantic proximity
Unveiling the role of KRAS in tumor immune microenvironment.Semantic proximity
Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.Semantic proximity
Immunomodulatory role of oncogenic alterations in non-small cell lung cancer: a review of implications for immunotherapy.Semantic proximity
Kras G12C- and G12D-driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models.Semantic proximity
NRF2 Participates in the Suppressive Tumor Immune Microenvironment of KRAS/KEAP1 Co-Mutant Non-Small Cell Lung Cancer by Inhibiting the STING PathwaySemantic proximity
Regulation of lung cancer initiation and progression by the stem cell determinant MusashiSemantic proximity
Select a neighboring publication to make it the new centre.