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Article

Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow.

Cell reports - 3 Aug 2021

Magod Prerna, Mastandrea Ignacio, Rousso-Noori Liat, Agemy Lilach, Shapira Guy, Shomron Noam, Friedmann-Morvinski Dinorah

Abstract excerpt

Recent multi-omics studies show different immune tumor microenvironment (TME) compositions in glioblastoma (GBM). However, temporal comprehensive knowledge of the TME from initiation of the disease remains sparse. We use Cre recombinase (Cre)-inducible lentiviral murine GBM models to compare the cellular evolution of the immune TME in tumors initiated from different oncogenic drivers. We show that neutrophils...

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Identifiers

PMID: 34348160
DOI: 10.1016/j.celrep.2021.109480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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