Article

CodonRL: Multi-Objective Codon Sequence Optimization Using Demonstration-Guided Reinforcement Learning

2026-02-14

Abstract excerpt

Optimizing synonymous codon sequences to improve translation efficiency, RNA stability, and compositional properties is challenging because the search space grows exponentially with protein length and objectives interact through long range RNA structure. Dynamic programming-based methods can provide strong solutions for fixed objective combinations but are difficult to extend to additional constraints. Deep genera...

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Literature Corpus work: 85de1203-e085-50c9-9702-94f1831c84e2
DOI: 10.64898/2026.02.12.705465

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