Article
Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders.
Experimental & molecular medicine - 1 Jun 2023
Jung Kyeongmin, Yoon Joohyun, Ahn Yeeun, Kim Soyeon, Shim Injeong, Ko Hyunwoong, Jung Sang-Hyuk, Kim Jaeyoung, Kim Hyejin, Lee Dong June, Cha Soojin, Lee Hyewon, Kim Beomsu, Cho Min Young, Cho Hyunbin, Kim Dan Say, Kim Jinho, Park Woong-Yang, Park Tae Hwan, O Connell Kevin S, Andreassen Ole A, Myung Woojae, Won Hong-Hee
Abstract excerpt
Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify the genetic variants associated with irritability and investigate the associated biological pathways, genes, and tissues as well as single-nucleotide polymorphism (SNP)-based heritability; 2) explore the relationships between...
Topics
- Humans
- Depressive Disorder, Major
- Genome-Wide Association Study
- Genetic Predisposition to Disease
- Bipolar Disorder
- Schizophrenia
- Polymorphism, Single Nucleotide