Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology.

Psychological medicine - 1 Jul 2015

Hettema J M, Chen X, Sun C, Brown T A

Abstract excerpt

BACKGROUND: Twin studies of internalizing disorders suggest that their high co-morbidity is partially explained by shared genetic risk. Few studies have investigated pleiotropic effects of well-validated candidate genes across phenotypes. METHOD: Subjects were 928 Caucasian patients who presented to an out-patient clinic specializing in the assessment and treatment of anxiety and mood disorders. We constructed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety Disorders
Share to Boston
Share to Glutamate Decarboxylase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interview, Psychological

Share to Mood Disorders

Share to Psychopathology

Share to RGS Proteins

Share to Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 25702797
DOI: 10.1017/S0033291715000021
PMCID: PMC6988508

Genes

COMT
GAD1
RGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology.PMID 25702797Read ↗

A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology SpectraSemantic proximity Read ↗

The boundaries of the internalizing and externalizing genetic spectra in men and women.Semantic proximity Read ↗

Identification of pleiotropy at the gene level between psychiatric disorders and related traitsSemantic proximity Read ↗

Mapping the genetic landscape across 14 psychiatric disorders.Semantic proximity Read ↗

Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing PsychopathologySemantic proximity Read ↗

Shared Genetic Liability across Systems of Psychiatric and Physical Illness.Semantic proximity Read ↗

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing PsychopathologySemantic proximity Read ↗

The structure of genetic and environmental risk factors for syndromal and subsyndromal common DSM-IV axis I and all axis II disorders.Semantic proximity Read ↗

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders.Semantic proximity Read ↗

Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children.Semantic proximity Read ↗

Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology.Semantic proximity Read ↗

Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.