Article

Aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk

2022-11-29

Abstract excerpt

<h4>Rationale</h4> Aortic valve stenosis (AVS) is a major contributor to cardiovascular death in the elderly population worldwide. MicroRNAs (miRNAs) are highly dysregulated in patients with AVS undergoing surgical aortic valve replacement (SAVR). However, miRNA-dependent mechanisms regulating inflammation and calcification or miRNA-mediated cell-cell crossstalk during the pathogenesis of AVS are still poorly und...

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Literature Corpus work: 85d0b357-27c9-53cf-b4cc-681673e9eb74
DOI: 10.1101/2022.11.29.518326

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