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Article

Deletion of Lats 1 and 2 in mouse pancreatic acinar cells induces pancreatic fibrosis and inflammation

2019-01-23

Abstract excerpt

<h4>Objective</h4> The Hippo signaling pathway is known for regulating proliferation, differentiation, organ size, and tumorigenesis. Large tumor suppressor kinase 1 and 2 (LATS1&2) are the core kinases of this pathway, whose functions in both the normal pancreas and pancreatic diseases are unclear. We studied the function of LATS1&2 specifically in pancreatic acinar cells of adult mice. <h4>Design</h4> We gener...

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Identifiers and source

Literature Corpus work
590f870d-b82b-5127-ada3-149ac522f622
DOI
10.1101/522938
Open publication

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