Article

Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice

2023-08-25

Abstract excerpt

<h4>Background</h4> Dual specificity protein phosphatase 6 (DUSP6) was recently identified as a key hub gene in a causal network that regulates late-onset Alzheimer’s disease. Importantly, decreased DUSP6 levels are correlated with an increased clinical dementia rating in human subjects, and DUSP6 levels are additionally decreased in the 5xFAD amyloidopathy mouse model. <h4>Methods</h4> AAV5-DUSP6 or AAV5-GFP (c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80a0fa97-ec92-5271-9240-8fb297e7c134
DOI: 10.1101/2023.08.24.554335

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD miceDOI 10.1101/2023.08.24.554335Read

Sex‐biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: A multi‐omic analysisSemantic proximity Read

Sex specific molecular networks and key drivers of Alzheimer’s diseaseSemantic proximity Read

Age, Sex and Alzheimer’s disease: A longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patientsSemantic proximity Read

Transcriptional Dysregulation in the Hippocampus of a murine model for Parkinson’s Disease Cognition Impairment is Driven by Sex, Age, and Alpha-synuclein overexpressionSemantic proximity Read

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD miceSemantic proximity Read

Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau PathologiesSemantic proximity Read

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s diseaseSemantic proximity Read

Spatiotemporal Characterization of Amyloidosis-Associated Microglial States Reveals Sex Difference in Early Plaque FormationSemantic proximity Read

Sex, not estrous cycle stage, drives differences in the microglial transcriptome in the 5xFAD mouse model of amyloidosisSemantic proximity Read

TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer’s Disease MiceSemantic proximity Read

AETA peptide contributes to Alzheimer’s disease signature of synapse dysfunctionSemantic proximity Read

X Chromosome Factor Kdm6a Enhances Cognition Independent of Its Demethylase Function in the Aging XY Male BrainSemantic proximity Read