Article

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)

2003-10-01

Abstract excerpt

Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to sinus node dysfunction and diagnosed by electrocardiographic demonstration of sinus bradycardia or sinus arrest. Although frequently associated with underlying heart disease and seen most often in the elderly, SSS may occur in the fetus, infant, and child without apparent cause. In this setting, SSS is presumed to be congenital. Based on pri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85af94cb-ae79-507b-afe7-9a975adaecba
DOI: 10.1172/jci200318062

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)DOI 10.1172/jci200318062Read

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A).Semantic proximity Read

Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics.Semantic proximity Read

A novel homozygous SCN5A variant detected in sick sinus syndrome.Semantic proximity Read

Genetic Na+ channelopathies and sinus node dysfunction.Semantic proximity Read

Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction.Semantic proximity Read

Sodium channel mutations and arrhythmias.Semantic proximity Read

Inherited disorders of voltage-gated sodium channelsSemantic proximity Read

Inherited sodium channelopathies: a continuum of channel dysfunction.Semantic proximity Read

Cardiac Arrhythmias Related to Sodium Channel Dysfunction.Semantic proximity Read

A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families.Semantic proximity Read

Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects.Semantic proximity Read

A homozygous SCN5A mutation in a severe, recessive type of cardiac conduction disease.Semantic proximity Read