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Article

Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction.

Heart rhythm - 1 May 2017

Ishikawa Taisuke, Ohno Seiko, Murakami Takashi, Yoshida Kentaro, Mishima Hiroyuki, Fukuoka Tetsuya, Kimoto Hiroki, Sakamoto Risa, Ohkusa Takafumi, Aiba Takeshi, Nogami Akihiko, Sumitomo Naokata, Shimizu Wataru, Yoshiura Koh-Ichiro, Horigome Hitoshi, Horie Minoru, Makita Naomasa

Abstract excerpt

BACKGROUND: Familial sick sinus syndrome (SSS) is often attributable to mutations in genes encoding the cardiac Na channel SCN5A and pacemaker channel HCN4. We previously found that SSS with SCN5A mutations shows early onset of manifestations and male predominance. Despite recent reports on the complications of atrial fibrillation (AF) and left ventricular noncompaction (LVNC) in patients with SSS caused by HCN4...

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Source

Identifiers

PMID: 28104484
DOI: 10.1016/j.hrthm.2017.01.020

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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