Article
Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics.
Circulation. Arrhythmia and electrophysiology - 1 Jun 2014
Abe Keisuke, Machida Taku, Sumitomo Naokata, Yamamoto Hirokazu, Ohkubo Kimie, Watanabe Ichiro, Makiyama Takeru, Fukae Satoki, Kohno Masaki, Harrell Daniel T, Ishikawa Taisuke, Tsuji Yukiomi, Nogami Akihiko, Watabe Taichi, Oginosawa Yasushi, Abe Haruhiko, Maemura Koji, Motomura Hideki, Makita Naomasa
Abstract excerpt
BACKGROUND: Sick sinus syndrome (SSS) is a common arrhythmia often associated with aging or organic heart diseases but may also occur in a familial form with a variable mode of inheritance. Despite the identification of causative genes, including cardiac Na channel (SCN5A), the pathogenesis and molecular epidemiology of familial SSS remain undetermined primarily because of its rarity. METHODS AND RESULTS: We...
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