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Article

Inherited disorders of voltage-gated sodium channels

1 Aug 2005

Abstract excerpt

A variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm, and nervous system function have been traced to mutations in genes encoding voltage-gated sodium channels. Clinical severity among these conditions ranges from mild or even latent disease to life-threatening or incapacitating conditions. The sodium channelopathies were among the first recognized ion channel diseases and...

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PMID: 16075039
DOI: 10.1172/jci25505

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