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Article

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A).

The Journal of clinical investigation - 1 Oct 2003

Benson D Woodrow, Wang Dao W, Dyment Macaira, Knilans Timothy K, Fish Frank A, Strieper Margaret J, Rhodes Thomas H, George Alfred L

Abstract excerpt

Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to sinus node dysfunction and diagnosed by electrocardiographic demonstration of sinus bradycardia or sinus arrest. Although frequently associated with underlying heart disease and seen most often in the elderly, SSS may occur in the fetus, infant, and child without apparent cause. In this setting, SSS is presumed to be congenital. Based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14523039
DOI: 10.1172/JCI18062
PMCID: PMC198523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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