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Article

Cardiac Arrhythmias Related to Sodium Channel Dysfunction.

Handbook of experimental pharmacology - 1 Jan 2018

Savio-Galimberti Eleonora, Argenziano Mariana, Antzelevitch Charles

Abstract excerpt

The voltage-gated cardiac sodium channel (Nav1.5) is a mega-complex comprised of a pore-forming α subunit and 4 ancillary β-subunits together with numerous protein partners. Genetic defects in the form of rare variants in one or more sodium channel-related genes can cause a loss- or gain-of-function of sodium channel current (INa) leading to the manifestation of various disease phenotypes, including Brugada...

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Identifiers

PMID: 28965168
DOI: 10.1007/164_2017_43

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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