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In Staphylococcus aureus , the acyl-CoA synthetase MbcS supports branched-chain fatty acid synthesis from carboxylic acid and aldehyde precursors

2023-11-11

Abstract excerpt

In the human pathogen Staphylococcus aureus , branched-chain fatty acids (BCFAs) are the most abundant fatty acids in membrane phospholipids, and strains deficient for their synthesis experience BCFAs auxotrophy in laboratory culture and attenuated virulence during infection. Thus, membrane integrity is essential for S. aureus pathogenesis. Furthermore, the membrane of S. aureus is among the main targets for an...

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Literature Corpus work
858e8a6c-6cae-54bc-b740-181f2d3731b2
DOI
10.22541/au.169972360.09241584/v1
Open publication

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