Article

Latent EBV impairs immune cell signaling and enhances the efficacy of anti-CD3 mAb in Type 1 Diabetes

2023-07-13

Abstract excerpt

<h4>Summary</h4> Teplizumab has been approved for the delay of the onset of type 1 diabetes and may modulate new onset disease. We found that patients who were EBV positive at baseline had a more robust response to drug in two clinical trials and therefore postulated that latent virus has general effects in modifying immune responses. We compared the phenotypes, transcriptomes, and development of peripheral blood...

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Literature Corpus work: 4ef2f106-58c4-5259-bfcf-eaa1fb346b77
DOI: 10.1101/2023.07.11.23292344

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