Article

Preproinsulin-specific regulatory T cell-derived exosomes loaded with immune checkpoint ligands can suppress autoimmune responses in type 1 diabetes

2025-01-06

Abstract excerpt

<title>Abstract</title> <p>Background Type 1 diabetes (T1D) is an autoimmune disease, caused by selective destruction of pancreatic beta cells, mediated mainly by infiltrating CD8 + T cells. These CD8 + T cells also express immune checkpoint molecules (ICMs) which can be targeted by specific immune checkpoint ligands (ICLs) as well as beta cell-specific regulatory T cells (Tregs) to induce immunosuppression. Met...

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Literature Corpus work: 3d2518a0-9c08-5fbe-8a0a-3fa71638f23d
DOI: 10.21203/rs.3.rs-5755719/v1

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Preproinsulin-specific regulatory T cell-derived exosomes loaded with immune checkpoint ligands can suppress autoimmune responses in type 1 diabetesDOI 10.21203/rs.3.rs-5755719/v1Read

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