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Article

Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency.

Scientific reports - 15 Apr 2016

Frank Viktoria, Kaufmann Stefan, Wright Rebecca, Horn Patrick, Yoshikawa Hiroshi Y, Wuchter Patrick, Madsen Jeppe, Lewis Andrew L, Armes Steven P, Ho Anthony D, Tanaka Motomu

Abstract excerpt

Mounting evidence indicated that human mesenchymal stem cells (hMSCs) are responsive not only to biochemical but also to physical cues, such as substrate topography and stiffness. To simulate the dynamic structures of extracellular environments of the marrow in vivo, we designed a novel surrogate substrate for marrow derived hMSCs based on physically cross-linked hydrogels whose elasticity can be adopted...

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Source

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Identifiers

PMID: 27080570
DOI: 10.1038/srep24264
PMCID: PMC4832181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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