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Article

Neurotrophins and dementia--keeping in touch.

Neuron - 6 Jul 2006

Castrén Eero, Tanila Heikki

Abstract excerpt

Down's syndrome patients develop dementia similar to Alzheimer's disease and show elevated levels of amyloid precursor protein in brain. Two papers in this issue of Neuron show that reduced retrograde transport or signaling of the neurotrophins NGF or BDNF, respectively, may account for the neuronal pathology in mouse models of Down's syndrome.

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Share to Alzheimer Disease
Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nerve Growth Factors

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Share to Receptors, Nerve Growth Factor

Source

Identifiers

PMID: 16815323
DOI: 10.1016/j.neuron.2006.06.019

Genes

BDNF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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