Article

Enhancing cancer targeting of γ9δ2TCR through modified NKG2D co-stimulation

2021-01-07

Abstract excerpt

Despite the ability of γδT cells to mediate tumor killing independently of MHC recognition, all the clinical trials that have been carried out using these cells showed low response rate in patients, in part due to its poor proliferation ability. Recently, a new generation of CAR-T cells called αβT cells engineered to express a defined γδTCR (TEG) has been developed. TEGs are αβT cells engineered to express a defin...

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Literature Corpus work: 84f3a7e1-9537-5251-9670-64323a1a5eeb
DOI: 10.1101/2021.01.06.424553

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