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Article

The potential of γδ CAR and TRuC T cells: An unearthed treasure

27 Aug 2024

Abstract excerpt

Recent years have witnessed the success of αβ T cells engineered to express chimeric antigen receptors (CARs) in treating haematological cancers. CARs combine the tumour antigen binding capability of antibodies with the signalling functions of the T-cell receptor (TCR) ζ chain and co-stimulatory receptors. Despite the success, αβ CAR T cells face limitations. Possible solutions would be the use of γδ T cells and...

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PMID: 39192467
DOI: 10.1002/eji.202451074

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