Article

CEA-4-1BBL: Design and Optimization of a Novel CEACAM5-Targeted 4-1BB Ligand Antibody Fusion Protein to Provide Costimulation in Cis in Combination with T Cell Bispecific Antibodies

2025-09-30

Abstract excerpt

<h4>Background: </h4> /Objectives: T cell bispecific antibodies (TCBs) activate T cells for the killing of tumor cells upon binding to tumor antigens resulting in the activation of T cell receptor signaling providing the so-called signal 1 to T cells. In order to enhance and sustain the activity of T cells a co-stimulatory signal 2 is required. Here we describe CEACAM5-targeted 4-1BBL antibody fusion protein for c...

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Literature Corpus work: 7798b5cd-ed30-511f-abc9-96eaca1a60b1
DOI: 10.20944/preprints202509.2415.v1

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