Article
Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation.
Molecular therapy : the journal of the American Society of Gene Therapy - 7 Feb 2018
Capsomidis Anna, Benthall Gabriel, Van Acker Heleen H, Fisher Jonathan, Kramer Anne M, Abeln Zarah, Majani Yvonne, Gileadi Talia, Wallace Rebecca, Gustafsson Kenth, Flutter Barry, Anderson John
Abstract excerpt
Gamma delta T (γδT) lymphocytes are primed for rapid function, including cytotoxicity toward cancer cells, and are a component of the immediate stress response. Following activation, they can function as professional antigen-presenting cells. Chimeric antigen receptors (CARs) work by focusing T cell function on defined cell surface tumor antigens and provide essential costimulation for robust activation. Given...
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