Article

A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands

2025-04-21

Abstract excerpt

<title>Abstract</title> Adoptive therapies using T cells genetically modified with T cell receptors (TCR)s have shown limited efficacy in the solid tumor setting. Although functional CD4 + and CD8 + T cells transduced with a TCR specific for HLA-A2-restricted melanoma-associated antigen A1 (MAGE-A1, T TCR−MA1−CD8αβ ) could be detected post-transfer and were safe in one...

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Literature Corpus work: 5a8df3dc-338d-5236-a56c-a1ddf4ff07b7
DOI: 10.21203/rs.3.rs-5939098/v1

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