Article

CEA-4-1BBL: CEACAM5-Targeted 4-1BB Ligand Fusion Proteins for Cis Co-Stimulation with CEA-TCB

2025-10-30

Abstract excerpt

<h4>Background: </h4> /Objectives: T cell bispecific antibodies (TCBs) result in the activation of T cell receptor signaling upon binding to tumor antigens providing signal 1 to T cells. To enhance and sustain their activity a co-stimulatory signal 2 is required. Here CEACAM5-targeted 4-1BBL antibody fusion proteins for combination with CEA-TCB (cibisatamab, RG7802) are described to investigate the relationship of...

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Literature Corpus work: db6c274c-0fd4-5e6a-968e-3ad1e7e0f156
DOI: 10.20944/preprints202509.2415.v2

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