Article

Different genetic mechanisms mediate spontaneous versus UVR-induced malignant melanoma

2018-10-16

Abstract excerpt

Genetic variation conferring resistance and susceptibility to carcinogen-induced tumorigenesis is frequently studied in mice. We have now turned this to melanoma using the collaborative cross (CC), a resource of mouse strains designed to discover genes for complex diseases. We studied melanoma-prone transgenic progeny across seventy CC genetic backgrounds. We mapped a strong quantitative trait locus for rapid onse...

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Identifiers and source

Literature Corpus work: 84eefc35-5979-5394-bb28-7522b8cb8253
DOI: 10.1101/443697

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