Article
Melanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progression.
Oncogene - 28 May 2015
Ferguson B, Ram R, Handoko H Y, Mukhopadhyay P, Muller H K, Soyer H P, Morahan G, Walker G J
Abstract excerpt
Susceptibility to most common cancers is likely to involve interaction between multiple low risk genetic variants. Although there has been great progress in identifying such variants, their effect on phenotype and the mechanisms by which they contribute to disease remain largely unknown. We have developed a mouse melanoma model harboring two mutant oncogenes implicated in human melanoma, CDK4(R24C) and...
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