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Article

Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2017

Knatko Elena V, Praslicka Brandon, Higgins Maureen, Evans Alan, Purdie Karin J, Harwood Catherine A, Proby Charlotte M, Ooi Aikseng, Dinkova-Kostova Albena T

Abstract excerpt

Cutaneous squamous cell carcinomas (cSCC) are among the most common and highly mutated human malignancies. Solar UV radiation is the major factor in the etiology of cSCC. Whole-exome sequencing of 18 microdissected tumor samples (cases) derived from SKH-1 hairless mice that had been chronically exposed to solar-simulated UV (SSUV) radiation showed a median point mutation (SNP) rate of 155 per Mb. The majority...

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Source

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Identifiers

PMID: 27923803
DOI: 10.1158/1940-6207.CAPR-16-0218
PMCID: PMC5408961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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