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Article

Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype.

Science signaling - 21 Nov 2017

Midgley Adam C, Oltean Sebastian, Hascall Vincent, Woods Emma L, Steadman Robert, Phillips Aled O, Meran Soma

Abstract excerpt

The cell surface protein CD44 is involved in diverse physiological processes, and its aberrant function is linked to various pathologies such as cancer, immune dysregulation, and fibrosis. The diversity of CD44 biological activity is partly conferred by the generation of distinct CD44 isoforms through alternative splicing. We identified an unexpected function for the ubiquitous hyaluronan-degrading enzyme,...

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Source

Identifiers

PMID: 29162741
DOI: 10.1126/scisignal.aao1822

Genes

HYAL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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