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In silico Approach for Exploring the Role of AT1R Polymorphism on its Function, Structure and Drug Interactions

26 Oct 2020

Abstract excerpt

BACKGROUND: AT1R (Angiotensin II type 1 receptor) is the main component of RAS (renin-angiotensin system) system, which activates when ANG II (angiotensin II) binds to it. AT1R helps in maintaining osmotic homeostasis and blood pressure regulation. A huge number of polymorphism are associated with AT1R and few of them were studied and found to be associated with the diseases and drug efficacy. Although it is a...

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PMID: 33100208
DOI: 10.2174/1573409916666201023113709

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